Based on the principle of Solid Phase Reverse Immobilization (SPRI), QKGEN® AT DNA Clean Beads have been mobilized with carefully optimized buffer systems to separate and purify DNA fragments during second-generation sequencing library construction. This product can be applied to various brands of DNA and RNA library building kits, which are used in the same way as the widely used AMPure XP Beads at present, and the fragment recovery efficiency and library size distribution are highly consistent with AMPure XP Beads.